Project Title: Dynamic Residual Antibiotic drug concentration in blood as a monitoring tool for evaluation population medicine usage and the impact of antibiotic stewardship intervention on drug pressure
Project Description: Assessment of antimicrobials use relies either on the longitudinal recording of stocks, prescription rates in health facilities, and health insurance reimbursement data, or on medication use by individuals recorded in community surveys. These measures are potentially biased and do not provide accurate estimates of levels of circulating drugs at the community level, which is likely the most important driver for the development of antimicrobial-resistant pathogens. Objective and standardized measurements of drug blood concentration at the... Assessment of antimicrobials use relies either on the longitudinal recording of stocks, prescription rates in health facilities, and health insurance reimbursement data, or on medication use by individuals recorded in community surveys. These measures are potentially biased and do not provide accurate estimates of levels of circulating drugs at the community level, which is likely the most important driver for the development of antimicrobial-resistant pathogens. Objective and standardized measurements of drug blood concentration at the population level should provide more reliable assessment of overall medicine use and pressure. They would also allow evaluating the public health impact of interventions that target at improving appropriate antibiotic and antimalarial treatment. Goal To assess antimicrobial drug pressure at the population level, and evaluate the impact of antibiotic stewardship interventions on antimicrobial drug pressure Main objectives 1) To estimate the prevalence of individuals with residual antibiotic drugs in the blood in a representative sample of the population in three districts of Tanzania with different level of malaria endemicity, and to explore the factors that determine antibiotic use 2) To obtain spatially explicit estimates of the burden of antibiotic use in the three districts 3) To assess the impact of antimicrobial stewardship intervention (electronic algorithm for the management of children with fever [e-POCT]) on medicines (antibiotics and antimalarials) use (pressure) in the population of children<10 years Relevance and impact of the project - To tackle the global public health threat of antimicrobial resistance (AMR) and address one of the specific step, namely improving global surveillance of antimicrobial consumption in humans as mentioned in the national strategic programme StAR, the WHO Global Action Plan and the UK final report and recommendations on AMR - To provide an inovative standardized and reliable approach to quantify real antibiotic and antimalarial drug use and pressure at the community level - To provide a new tool to assess the impact of interventions aimed at improving the rational use of medicines (antibiotics and antimalarials)
Principal Investigator : Irene Masanja
Department Name : HSIEP
Time frame: (2019-11-11) - (2022-04-10)
Swiss Tropical and Public Health Institute (Normal)
External Collaborating Partners
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